The Joseph-Antoine Maury 2024 Prize was awarded by the National Academy of Medicine on Tuesday December 17 to Pr. Guedj and his team for their research on long Covid at the Institut Fresnel (amU/CNRS/Centrale Méditerranée). This work on Covid sequelae had already been doubly honored in November 2024 by AuntMinnie media, the leading media platform for medical imaging, with awards in the Image of the Year and Scientific Article of the Year categories.
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The Joseph-Antoine Maury Prize is awarded to anyone who has found a way to relieve or alleviate physical human suffering. Two million people in France suffer from COVID long. These post-acute after-effects mainly affect young, active individuals, with a possible progression to chronicity, disability and stigmatization. The medico-economic impact is estimated at 1% of the world economy.
Molecular neuro-imaging research carried out by the IMoTheP team using Positron Emission Tomography (PET) has revealed a hypometabolic network with an olfactory pathway. This profile, found in both adult and pediatric patients, differs from that of psychiatric disorders or confinement-related physical deconditioning. Its severity correlates with symptom intensity, with very partial recovery over a 9-month follow-up. These studies also show a correlation between this late hypometabolism and an initial inflammatory hypermetabolism of these same regions. It could represent an astrocytic signature of glutamatergic deregulation linked to neuroinflammatory microglial activation.
This research has contributed to greater recognition of the cerebral reality of long COVID (the lead article has been the most cited in the European Journal of Nuclear Medicine and Molecular Imaging since 2021), and to the definition of PET imaging interpretation criteria integrated into European Nuclear Medicine guidelines.
Relive the award ceremony on video:
Aix-Marseille University (AMU) follows CNIL guidelines
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Reference :
Horowitz T, Pellerin L, Zimmer ER, Guedj E. Brain fog in long COVID: A glutamatergic hypothesis with astrocyte dysfunction accounting for brain PET glucose hypometabolism. Med Hypotheses. 2023
Guedj E, Campion JY, Dudouet P, et al. F-FDG brain PET hypometabolism in patients with long COVID. Eur J Nucl Med Mol Imaging. 2021
Article published on Monday, January 6, 2025.
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